Basic Information
| LncRNA/CircRNA Name | LINC02095 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR |
| Sample | The benign and non-tumorigenic MCF10A (M1) cells |
| Expression Pattern | up-regulated |
| Function Description | linc02095, reveal that it promotes breast cancer proliferation by facilitating the expression of oncogenic transcription factor, SOX9.Knockdown of linc02095 results in decreased BC cell proliferation, whereas its overexpression promotes cells proliferation. Linc02095-depleted cells display reduced expression of SOX9 concomitant with reduced RNA polymerase II occupancy at the SOX9 gene body as well as defective SOX9 mRNA export, implying that linc02095 positively regulates SOX9 transcription and mRNA export. |
| Pubmed ID | 31690584 |
| Year | 2020 |
| Title | LncRNA-mediated Regulation of SOX9 Expression in Basal Subtype Breast Cancer Cells |
External Links
| Links for LINC02095 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |