Basic Information
| LncRNA/CircRNA Name | LINC01857 |
| Synonyms | NA |
| Region | GRCh38_2:207662375-207667024 |
| Ensemble | ENSG00000224137 |
| Refseq | NR_135567 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | glioma tissues and corresponding adjacent normal tissues ,Glioma cell lines and primary normal human astrocytes |
| Expression Pattern | up-regulated |
| Function Description | LINC01857 levels were found to be upregulated in glioma.LINC01857 expression is negatively correlated with survival rate in glioma patients.LINC01857 downregulation impaired glioma proliferation and invasiveness. Furthermore, LINC01857 knockdown led to repressed growth of glioma in vivo.LINC01857 could be a sponge for miR-1281 and inhibits its level to upregulate TRIM65 expression.miR-1281 mimics also attenuated tumor cell proliferation, migration, and invasion.LINC01857 promotes glioma progression through modulating miR-1281/TRIM65 pathway. |
| Pubmed ID | 31049960 |
| Year | 2019 |
| Title | LncRNA LINC01857 Promotes Growth, Migration, and Invasion of Glioma by Modulating miR-1281/TRIM65 Axis |
External Links
| Links for LINC01857 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |