Basic Information
| LncRNA/CircRNA Name | LINC01561 |
| Synonyms | NA |
| Region | GRCh38_10:120597949-120600124 |
| Ensemble | ENSG00000177234 |
| Refseq | NR_103717 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | breast cancer cell lines (MCF7, BT-20, ZR-75-1, and MX-1) |
| Expression Pattern | up-regulated |
| Function Description | qRT-PCR results identified that in BrCa cell lines, linc01561 and MMP11 were higher expressed while miR-145-5p was lower expressed compared with those in epithelial cell line. The linc01561 inhibition elevated miR-145-5p expression and then suppressed MMP11 expression. Moreover, linc01561 inhibition suppressed the BrCa cells proliferation and promoted the apoptosis, which was realized by up-regulating expression of miR-145-5p and down-regulating expression of MMP11. |
| Pubmed ID | 29890225 |
| Year | 2018 |
| Title | Mixomics Analysis of Breast Cancer: Long Non-Coding RNA linc01561 Acts as ceRNA Involved in the Progression of Breast Cancer |
External Links
| Links for LINC01561 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |