Basic Information
| LncRNA/CircRNA Name | LINC01559 |
| Synonyms | NA |
| Region | GRCh38_12:13371089-13387167 |
| Ensemble | ENSG00000180861 |
| Refseq | NR_036555 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | immortalized non-neoplastic pancreatic ductal epithelium cell (HPDE6-C7), human embryonic kidney cell (HEK-293T), and human pancreatic cancer cells (PANC-1, SW1990, BXPC-3, MIA- PaCa-2, and AsPC-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC01559 was at a low expression in normal pancreatic tissues but was obviously upregulated in PAAD tissues.LINC01559 was stimulated in PC cell lines relative to normal controls.LINC01559 facilitated PC cell proliferation and migration in vitro. Also, silencing LINC01559 obstructed PC cell growth in vivo. LINC01559 was revealed to be mainly in the cytoplasm of PC cells and therefore served as a ceRNA of Yes-associated protein (YAP) in PC cells via sponging miR-607.LINC01559 could interact with YAP protein, which might hinder YAP phosphorylation and enhance YAP transcriptional activity in PC cells. Furthermore,YAP was the downstream effector in LINC01559-regulated PC development. |
| Pubmed ID | 31608998 |
| Year | 2019 |
| Title | LINC01559 Accelerates Pancreatic Cancer Cell Proliferation and Migration Through YAP-mediated Pathway |
External Links
| Links for LINC01559 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |