Basic Information
| LncRNA/CircRNA Name | LINC01518 |
| Synonyms | NA |
| Region | GRCh38_10:42674197-42691723 |
| Ensemble | ENSG00000233515 |
| Refseq | NR_120659 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oesophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter assay, Western blot analysis |
| Sample | ESCC cell lines (Ec9706, Eca109, TE-1 and KYSE140) and the normal human oesophageal epithelial cell line (Het-1A) |
| Expression Pattern | up-regulated |
| Function Description | LINC01518 expression was upregulated and miR-1-3p expression was downregulated in ESCC cells. LINC01518 knockdown inhibited cell proliferation and promoted apoptosis in ESCC cells. In addition, LINC01518 functioned as a competing endogenous RNA (ceRNA) for miR-1-3p in ESCC cells and miR-1-3p downregulation blocked the effects of LINC01518 knockdown on cell proliferation and apoptosis in ESCC cells. |
| Pubmed ID | 31810385 |
| Year | 2019 |
| Title | LINC01518 Knockdown Inhibits Tumorigenicity by Suppression of PIK3CA/Akt Pathway in Oesophageal Squamous Cell Carcinoma |
External Links
| Links for LINC01518 | GenBank HGNC NONCODE |
| Links for oesophageal squamous cell carcinoma | OMIM COSMIC |