Basic Information
| LncRNA/CircRNA Name | LINC01494 |
| Synonyms | NA |
| Region | GRCh38_2:218900811-218930636 |
| Ensemble | ENSG00000228135 |
| Refseq | NR_110238 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR etc. |
| Sample | glioma tissues and responding normal controls, glioma cell lines( U87, U251, LN229 and A172 cells), and human astrocyte cell line (NHA) |
| Expression Pattern | up-regulated |
| Function Description | LINC01494 was identified as a significantly upregulated lncRNA in glioma. LINC01494 upregulation indicated poor prognosis. Meanwhile, in vitro investigation indicated that silencing LINC01494 with siRNAs obviously inhibited the proliferation, cell cycle, migration and invasion of glioma cells. Besides, it is found that LINC01494 expression was negatively correlated with miR-122-5p. We demonstrated that LINC01494 inhibited miR-122-5p to upregulate CCNG1 expression through direct interaction. LINC01494/miR-122-5p/CCNG1 signaling cascade plays a critical role in regulating glioma cell proliferation, migration and invasion. |
| Pubmed ID | 31571916 |
| Year | 2019 |
| Title | lncRNA LINC01494 Promotes Proliferation, Migration And Invasion In Glioma Through miR-122-5p/CCNG1 Axis |
External Links
| Links for LINC01494 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |