Basic Information
| LncRNA/CircRNA Name | LINC01419 |
| Synonyms | NA |
| Region | GRCh38_8:83403758-83408900 |
| Ensemble | ENSG00000253898 |
| Refseq | NR_122034 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | 5-fluorouracil (5-FU) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP etc. |
| Sample | ESCC tissues and 38 morphologically normal tissues?,ECC lines (EC9706 and KYSE70) |
| Expression Pattern | up-regulated |
| Function Description | Elevated levels of LINC01419 and downregulated levels of GSTP1 in the ESCC tissues and cells.The silencing of LINC01419 led to decreased proliferation, increased apoptosis, and enhanced sensitivity to 5-FU in ESCC cells.LINC01419 could bind to the promoter region of the GSTP1 gene, resulting in elevated GSTP1 methylation and reduced GSTP1 levels via the recruitment of DNA methyltransferase among ESCC cells, whereby ESCC progression was stimulated accompanied by reduced ESCC cell sensitivity to 5-FU. GSTP1 demethylation by 5-Aza-CdR was observed to reverse the effects of LINC01419 overexpression in ESCC cells and the response to 5-FU. |
| Pubmed ID | 31019568 |
| Year | 2019 |
| Title | Overexpression of Long Noncoding RNA LINC01419 in Esophageal Squamous Cell Carcinoma and Its Relation to the Sensitivity to 5-fluorouracil by Mediating GSTP1 Methylation |
External Links
| Links for LINC01419 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |