Basic Information
| LncRNA/CircRNA Name | LINC01413 |
| Synonyms | NA |
| Region | GRCh38_15:57319138-57323908 |
| Ensemble | ENSG00000260172 |
| Refseq | NR_120337 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qRT-PCR, Western blot, RIP, Luciferase Reporter Assay, In Vivo Assays |
| Sample | tumor and adjacent non-tumor tissues,colon epithelial cell line (NCM460) and five CRC cell lines (SW480, SW620, HCT-116, HT-29, and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | an elevated level of LINC01413 expression in CRC tissues was strongly correlated to clinicopathological features, such as tumor size, tumor stage, lymph node metastasis, and distant metastasis, and its association with poor overall survival was also revealed. Additionally, LINC01413 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. Also, silenced LINC01413 restrains tumor growth in vivo. Moreover, LINC01413 binds with hnRNP-K and induces YAP1 (yes-associated protein 1)/TAZ1 (tafazzin) nuclear translocation to regulate the expression of ZEB1 in CRC cells. |
| Pubmed ID | 31927328 |
| Year | 2020 |
| Title | LINC01413/hnRNP-K/ZEB1 Axis Accelerates Cell Proliferation and EMT in Colorectal Cancer via Inducing YAP1/TAZ1 Translocation |
External Links
| Links for LINC01413 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |