Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colon cancer
ICD-0-3	C18
Methods	qPCR, Western blot, etc.
Sample	CC tissues, NCM460 colon epithelial cell line and a panel of CC cell lines (HT-29, HCT116, SW620 and LoVo)
Expression Pattern	up-regulated
Function Description	LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. It was indicated that high expression of LINC01410 in CC tissues was associated with poor prognosis. Further functional study suggested that LINC01410 knockdown significantly reduced the proliferation and invasive capacity of HT-29 and SW620 cells, and inhibited the cell cycle. Regarding the mechanism, LINC01410 was indicated to serve as a sponge for microRNA (miR)-3128, as evidenced by a luciferase reporter assay. Furthermore, knockdown of LINC01410 significantly increased the levels of miR-3128. In addition, miR-3128 was markedly downregulated in CC tissues compared with that in adjacent normal tissues. A rescue assay revealed that inhibition of miR 3128 significantly abrogated the effects of LINC01410 knockdown on CC cell proliferation and invasion.
Pubmed ID	30546401
Year	2018
Title	Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128

External Links