Basic Information
| LncRNA/CircRNA Name | LINC01391 |
| Synonyms | NA |
| Region | GRCh38_3:138935189-138944020 |
| Ensemble | ENSG00000244578 |
| Refseq | NR_121649 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | piplartine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | HepG2 and SMMC-7721 cell lines, tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | piplartine attenuated cell proliferation and invasion but promoted cell apoptosis. Upregulation of LINC01391 induced by piplartine inhibited HCC cell proliferation, invasion in vitro, and tumor growth in vivo. LINC01391 interacted with ICAT and promoted its inhibitory effect on the Wnt/?-catenin pathway, as enhanced interaction between ?-catenin and ICAT, and dampened interaction of ?-catenin and TCF/LEF were induced by overexpression of LINC01391. Knockdown of ICAT also promoted cell proliferation in vitro and tumor growth in vivo. |
| Pubmed ID | 31207322 |
| Year | 2019 |
| Title | Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/?-catenin pathway inactivation through ICAT |
External Links
| Links for LINC01391 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |