Basic Information
| LncRNA/CircRNA Name | LINC01354 |
| Synonyms | NA |
| Region | GRCh38_1:234527891-234531779 |
| Ensemble | ENSG00000231768 |
| Refseq | NR_038426 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | CRC specimens and adjacent normal tissues ,human CRC cell lines (HCT116, HT29, SW620, SW480 and LoVo) and normal colorectal epithelium cell line FHC |
| Expression Pattern | up-regulated |
| Function Description | The upregulation of LINC01354 in CRC and its prognostic significance were identified by TCGA database and confirmed in CRC tissues.Functionally, forced expression of LINC01354 promoted, while knockdown of LINC01354 inhibited cell proliferation, migration and EMT phenotype formation of CRC cells.A significant enrichment of the Wnt/?-catenin signaling pathway genes under LINC01354 overexpression. In addition, LINC01354 modulated the mRNA stability of ?-catenin through interacting with hnRNP-D, thereby activating Wnt/?-catenin signaling pathway. |
| Pubmed ID | 30987669 |
| Year | 2019 |
| Title | LINC01354 Interacting With hnRNP-D Contributes to the Proliferation and Metastasis in Colorectal Cancer Through Activating Wnt/?-catenin Signaling Pathway |
External Links
| Links for LINC01354 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |