Basic Information
| LncRNA/CircRNA Name | LINC01303 |
| Synonyms | NA |
| Region | GRCh38_14:61556313-61570653 |
| Ensemble | ENSG00000250548 |
| Refseq | NR_110416 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | gastric cancer tissues, GC cell lines BGC823, SGC 7901, MKN-45, AGC and immortalized human gastric epithelial cell line GES-1 |
| Expression Pattern | up-regulated |
| Function Description | the expression of LINC01303 was significantly higher in GC tissues than in adja cent tissues by real time quantitative PCR.?We can significantly inhibit the malignant proliferation, migration and invasion of GC cells by silencing LINC01303 expression.?In addition, LINC01303 knockdown can also inhibit GC growth in vivo.?After the bio informatics analysis, we found that LINC01303 can be used as a miR 101 3p sponge to competitively adsorb miR 101 3p with EZH2.?Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR 101 3p activity and promotes GC progression. |
| Pubmed ID | 31497936 |
| Year | 2019 |
| Title | LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR-101-3p in gastric cancer |
External Links
| Links for LINC01303 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |