Basic Information
| LncRNA/CircRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 |
| Ensemble | ENSG00000225210 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic Ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | PDAC tissues and cell lines (PANC-1, Capan-2, SW1990, BxPC-3) |
| Expression Pattern | up-regulated |
| Function Description | LINC01296 was enhanced in PDAC tissues and cell lines, and this overexpression was correlated with advanced tumor stages and positive lymph node metastasis in patients with PDAC. In addition, upregulation of LINC01296 was an independent prognostic predictor for patients with PDAC after surgery. Moreover, silencing of LINC01296 followed by treatment with small interfering RNAs suppressed cell proliferation and promoted cell apoptosis by affecting the Bcl-2/caspase-3 pathway. Importantly, LINC01296 attenuation impaired the migratory and invasive potential partly by reversing EMT. |
| Pubmed ID | 30203487 |
| Year | 2019 |
| Title | Upregulated Long Noncoding RNA LINC01296 Indicates a Dismal Prognosis for Pancreatic Ductal Adenocarcinoma and Promotes Cell Metastatic Properties by Affecting EMT |
External Links
| Links for LINC01296 | GenBank HGNC NONCODE |
| Links for pancreatic Ductal adenocarcinoma | OMIM COSMIC |