Basic Information
| LncRNA/CircRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 |
| Ensemble | ENSG00000225210 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | steosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | Osteosarcoma tissues and cell lines (hFOB1.19,MG63 and 143B) |
| Expression Pattern | up-regulated |
| Function Description | LINC01296 overexpression was demonstrated as a biomarker of osteosarcoma, which was closely correlated with the poor survival of patients with osteosarcoma. A high expression of LINC01296 was observed in osteosarcoma cells, which was closely associated with enhanced proliferation, invasion, and migration of osteosarcoma cells. Cyclin D1 expression was positively correlated with the expression of LINC01296 in osteosarcoma cells. Cyclin D1 knockdown or overexpression played a deterministic role in mediating the effect of LINC01296 on osteosarcoma cells. LINC01296 is an oncogenic lncRNA in osteosarcoma. The proliferation, invasion and migration of osteosarcoma cells could be effectively retarded by inhibition of LINC01296. |
| Pubmed ID | 30226542 |
| Year | 2018 |
| Title | lncRNA LINC01296 Regulates the Proliferation, Metastasis and Cell Cycle of Osteosarcoma Through Cyclin D1 |
External Links
| Links for LINC01296 | GenBank HGNC NONCODE |
| Links for steosarcoma | OMIM COSMIC |