Basic Information
| LncRNA/CircRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 |
| Ensemble | ENSG00000225210 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | HCC tissues and pericancerous tissues?,human HCC cell lines (SMMC-7721, Hep3B, HepG2, and Huh7) and normal hepatocyte cell line (HL-7702) |
| Expression Pattern | up-regulated |
| Function Description | A higher expression level was correlated with higher alpha fetoprotein levels, a larger tumor size, an advanced TNM stage, and a poorer overall survival rate. Upregulation of LINC01296 promoted the proliferation, migration, and invasion of HCC cells.Improvement of cell migration and invasion attributable to the overexpression of LINC01296 was related to an increase in epithelial-mesenchymal transition (EMT). Mechanistically, miR-122-5P can bind to LINC01296 and decrease its oncogenic effect. |
| Pubmed ID | 30988624 |
| Year | 2019 |
| Title | LINC01296 Promotes Proliferation, Migration, and Invasion of HCC Cells by Targeting miR-122-5P and Modulating EMT Activity |
External Links
| Links for LINC01296 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |