Basic Information
| LncRNA/CircRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 |
| Ensemble | ENSG00000225210 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | RT-qPCR, Dual luciferase reporter gene assay, RIP, Western blot analysis |
| Sample | tissue samples,TC cell lines BHT-101, IHH4, TPC-1, CGTHW-3 and human normal thyroid cell Nthy-ori 3-1 |
| Expression Pattern | up-regulated |
| Function Description | LINC01296 was up-regulated, while miR-143-3p was down-regulated in TC cells and tissues. LNC01296 specifically bound to miR-143-3p and MSI2 was a target of miR-143-3p. Besides, LINC01296 silencing or miR-143-3p overexpression inhibited migration, invasion, proliferation and advanced apoptosis of TC cells. Additionally, silenced LINC01296 or overexpressed miR-143-3p reduced phosphorylated STAT3/STAT3, phosphorylated AKT/AKT, B-cell lymphoma-2 (Bcl-2) and CyclinD1 levels but elevated BCL2-associated X (Bax), Cleaved Caspase3 and Caspase3 levels. |
| Pubmed ID | 31693087 |
| Year | 2019 |
| Title | Emerging Roles of the Long Non-Coding RNA 01296/microRNA-143-3p/MSI2 Axis in Development of Thyroid Cancer |
External Links
| Links for LINC01296 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |