Basic Information
| LncRNA/CircRNA Name | LINC01287 |
| Synonyms | TCONS_l2_00027522 |
| Region | GRCh38_7:153399920-153413963 |
| Ensemble | ENSG00000234722 |
| Refseq | NR_125776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot assay, ChIP, Luciferase reporter assay |
| Sample | HCC cell lines (HepG-2, Huh7, Bel7402 and Hep3B) and the normal liver epithelial cell line LO2, HCC tissues and matched normal tissue |
| Expression Pattern | up-regulated |
| Function Description | the expression of LINC01287 was increased in HCC cell lines, as well as tissues. Knockdown of LINC01287 decreased HCC cell growth and invasion both in vitro and in vivo. LINC01287 can negatively regulate miR-298 expression by acting as a ceRNA. miR-298 directly targeted STAT3 and inhibited its expression. LINC01287 exerted its function via the miR-298/STAT3 axis in HCC. Interestingly, STAT3 elevated LINC01287 expression via c-jun, which bound to the LINC01287 promoter. A feedback loop was also discovered between LINC01287 and the miR-298/STAT3 axis. |
| Pubmed ID | 30001751 |
| Year | 2018 |
| Title | LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells. |
External Links
| Links for LINC01287 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |