Basic Information
| LncRNA/CircRNA Name | LINC01287 |
| Synonyms | NA |
| Region | GRCh38_7:153399920-153413963 |
| Ensemble | ENSG00000234722 |
| Refseq | NR_125776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | BC and adjacent normal tissues ,cell lines( MCF-10A (as control cells), MDA-MB-468, MDAMB-453,MDAMB-231, and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | The levels of LINC01287 were significantly upregulated in BC tissues and BC cell lines, and the abnormal expressions of LINC01287 were correlated with TNM stage and lymph node metastasis.BC patients with higher LINC01287 expressions had significantly shorter overall survival than patients with lower LINC01287 expressions.LINC01287 expression was independently correlated with the overall survival.Si-LINC01287 transfection significantly inhibited the proliferation and metastasis of BC cells, and further promoted apoptosis.Besides,the knockdown of LINC01287 suppressed Wnt/?-catenin activation and affected the expressions of ?-catenin,cyclin D1, and c-myc. |
| Pubmed ID | 31173295 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC01287 Promotes Breast Cancer Cells Proliferation and Metastasis by Activating Wnt/?-catenin Signaling |
External Links
| Links for LINC01287 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |