Basic Information
| LncRNA/CircRNA Name | LINC01234 |
| Synonyms | NA |
| Region | GRCh38_12:113679459-113773683 |
| Ensemble | ENSG00000249550 |
| Refseq | NR_110026 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | Lung tumor tissues and adjacent normal lung tissues ,NSCLC cells (H1975, H1299, HCC827, A549, and SPC-A1) and BEAS-2B cells |
| Expression Pattern | up-regulated |
| Function Description | LINC01234 expressions were distinctly upregulated in both NSCLC samples and cell lines.LINC01234 upregulations were modulated by nuclear transcription factor SP1.High LINC01234 expressions were associated with positively lymph node metastasis and advanced tumor-metastasis-node (TMN) stage.Patients with NSCLC having high LINC01234 expressions tend to have unfavorable clinical prognosis. LINC01234 was an independent prognostic factor for patients with NSCLC.Inhibition of LINC01234 suppressed NSCLC cell proliferation, cell colony formation and metastasis, and greatly promoted apoptosis.LINC01234 promotes the progression of NSCLC cells by the modulation of miR-140 to positively regulate OTUB1 expression. |
| Pubmed ID | 31106421 |
| Year | 2019 |
| Title | SP1-mediated Overexpression of lncRNA LINC01234 as a ceRNA Facilitates Non-Small-Cell Lung Cancer Progression via Regulating OTUB1 |
External Links
| Links for LINC01234 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |