Basic Information
| LncRNA/CircRNA Name | LINC01234 |
| Synonyms | NA |
| Region | GRCh38_12:113679459-113773683 |
| Ensemble | ENSG00000249550 |
| Refseq | NR_110026 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot analysis, Dual Luciferase Reporter Assay, RIP |
| Sample | HepG2 and Huh7 cells |
| Expression Pattern | up-regulated |
| Function Description | LINC01234 downregulation could suppress the progression and chemoresistance in HCC by reducing miR-31-5p-mediated inhibition of MAGEA3.LINC01234 reduction could upregulate miR-31-5p to inhibit MAGEA3, leading to suppression in malignant phenotype of HCC cells. |
| Pubmed ID | 31838274 |
| Year | 2020 |
| Title | LINC01234/MicroRNA-31-5p/MAGEA3 Axis Mediates the Proliferation and Chemoresistance of Hepatocellular Carcinoma Cells |
External Links
| Links for LINC01234 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |