Basic Information
| LncRNA/CircRNA Name | LINC01234 |
| Synonyms | NA |
| Region | GRCh38_12:113679459-113773683 |
| Ensemble | ENSG00000249550 |
| Refseq | NR_110026 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Luciferase reporter assays, RIP, Western blot analysis |
| Sample | cell lines (A549, SPC-A1, H1299, and PC9,H226,16HBE),NSCLC specimens and adjacent noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC01234 expression is increased in NSCLC tissues, and its upregulation is associated with metastasis and shorter survival in NSCLC. Downregulation of LINC01234 impairs cell migration and invasion in vitro, and inhibits cells metastasis in vivo by acting as a competing endogenous RNA for the miR-340-5p and miR-27b-3p. LINC01234 also interacts with the RNA-binding proteins LSD1 and EZH2, leading to histone modification and transcriptional repression of the anti-proliferative genes BTG2. |
| Pubmed ID | 31959200 |
| Year | 2020 |
| Title | Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression |
External Links
| Links for LINC01234 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |