Basic Information
| LncRNA/CircRNA Name | LINC01207 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blotting, Microarray data analysis, RIP etc. |
| Sample | normal human pancreatic ductal epithelial cell line HPDE and pancreatic cancer cell lines (PANC-1, BxPC-3, Mpanc-96 and PaTu-8988) |
| Expression Pattern | up-regulated |
| Function Description | LINC01207 and AGR2 were highly expressed while miR-143-5p was poorly expressed in pancreatic cancer. Functionally, LINC01207 can bind to miR-143-5p, and AGR2 was a target gene of miR-143-5p. Importantly, silencing of LINC01207 down-regulated the expression of AGR2 by up-regulating miR-143-5p. Moreover, silencing of LINC01207 and up-regulation of miR-143-5p promoted cell apoptosis and autophagy, corresponding to increased expression of autophagy- and apoptosis-related proteins, in addition to inhibited cell growth. |
| Pubmed ID | 30991076 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC01207 Silencing Suppresses AGR2 Expression to Facilitate Autophagy and Apoptosis of Pancreatic Cancer Cells by Sponging miR-143-5p |
External Links
| Links for LINC01207 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |