Basic Information
| LncRNA/CircRNA Name | LINC01197 |
| Synonyms | NA |
| Region | GRCh38_15:95209099-95327129 |
| Ensemble | ENSG00000248441 |
| Refseq | NR_034095 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blotting, Northern blotting etc. |
| Sample | Eighteen fresh tumor tissues and matched adjacent tissues, HPNE, AsPC1, BxPC3, and PANC1 |
| Expression Pattern | down-regulated |
| Function Description | FOXO1-related lncRNA, LINC01197, was significantly decreased in PDAC malignant tissues and that its low expression predicted poor prognosis. Moreover, LINC01197 was mainly localized in the nucleus and inhibited PDAC cell proliferation both in vitro and in vivo. Mechanistically, LINC01197 was found to bind to ?-catenin and inhibit Wnt/?-catenin signaling activity by disrupting ?-catenin binding to TCF4 in PDAC cells. |
| Pubmed ID | 31027497 |
| Year | 2019 |
| Title | FOXO1-regulated lncRNA LINC01197 Inhibits Pancreatic Adenocarcinoma Cell Proliferation by Restraining Wnt/?-catenin Signaling |
External Links
| Links for LINC01197 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |