Basic Information
| LncRNA/CircRNA Name | LINC01186 |
| Synonyms | NA |
| Region | GRCh38_X:46325924-46327645 |
| Ensemble | ENSG00000236751 |
| Refseq | NR_110388 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNAi, Western blot, Cell migration and invasion assay etc. |
| Sample | cell lines (A549, H1299 and 293T) |
| Expression Pattern | down-regulated |
| Function Description | The expression of LINC01186 was significantly decreased in A549 cells treated with TGF-B1. Moreover, knocking-down LINC01186 promoted cell migration and invasion, whereas, LINC01186 overexpression prevented cell metastasis. Importantly, LINC01186 expression was regulated by SMAD3. And LINC01186 affected several EMT markers expression. |
| Pubmed ID | 28119085 |
| Year | 2017 |
| Title | Long noncoding RNA LINC01186, regulated by TGF-B/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer. |
External Links
| Links for LINC01186 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |