Basic Information
| LncRNA/CircRNA Name | LINC01138 |
| Synonyms | LINC01138, LINC00875 |
| Region | GRCh38_1:148290889-148519604 |
| Ensemble | ENSG00000274020 |
| Refseq | NR_027468 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, other |
| Sample | ccRCC cell lines |
| Expression Pattern | up-regulated |
| Function Description | Mechanistically, we demonstrated that LINC01138 interacts with PRMT5 to increase arginine methylation and protein stability of SREBP1, promoting lipid desaturation and cell proliferation in ccRCC. Our study identified LINC01138 as a novel regulator of metabolic abnormalities in ccRCC, providing a potential therapeutic target for metabolic therapy. |
| Pubmed ID | 30446222 |
| Year | 2018 |
| Title | The LINC01138 Interacts With PRMT5 to Promote SREBP1-mediated Lipid Desaturation and Cell Growth in Clear Cell Renal Cell Carcinoma |
External Links
| Links for LINC01138 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |