Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay etc. |
| Sample | osteosarcoma tissues, cell lines (C33A, Caski and SiHa) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of ANRIL was upregulated in 15 pairs of osteosarcoma compared with adjacent normal tissues. We found that hypoxia is sufficient to upregulate ANRIL expression in osteosarcoma cells (MNNG and U2OS). HIF-1a directly binds to the putative hypoxia response element in the upstream region of ANRIL. |
| Pubmed ID | 27688736 |
| Year | 2016 |
| Title | Long noncoding RNA ANRIL is activated by hypoxia-inducible factor-1a and promotes osteosarcoma cell invasion and suppresses cell apoptosis upon hypoxia. |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |