Basic Information
| LncRNA/CircRNA Name | LINC01133 |
| Synonyms | NA |
| Region | GRCh38_1:159961218-159984750 |
| Ensemble | ENSG00000224259 |
| Refseq | NR_038849 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | Breast cancer cell lines MDA-MB-231, MDA-MB-468, HCC1937, T47D, MCF7, ZR-75-1, BT-20, HCC1143, BT549 and Hs578T cells, human breast (and colon) tissues |
| Expression Pattern | up-regulated |
| Function Description | MSCs strongly induced the long non-coding RNA (lncRNA) LINC01133 in neighboring TNBC cells. Indeed, although lncRNAs have been tightly associated with cancer development, their contributions to breast cancer in general, and to TNBC pathogenesis in particular, have not been fully elucidated, and we set out to determine if LINC01133 regulated malignant traits in TNBC cells. We establish that LINC01133 is sufficient, on its own, in promoting phenotypic and growth characteristics of cancer stem cell (CSC) -like cells, and that it is a direct mediator of the MSC-triggered miR-199aFOXP2 pathway in TNBC models. Furthermore, we show that LINC01133 is a critical regulator of the pluripotency-determining gene Kruppel-Like Factor 4 (KLF4), and that it represents a biomarker and prognosticator of disease outcome in the clinic. |
| Pubmed ID | 31283068 |
| Year | 2019 |
| Title | Microenvironmental regulation of long non-coding RNA LINC01133 promotes cancer-stem-cell-like phenotypic traits in triple-negative breast cancers |
External Links
| Links for LINC01133 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |