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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot, in vitro knockdown, etc.
Sample	HepG2, Hep3B, MHCC-97L, SK-Hep-1, MHCC-97H, and HL-7702 cells
Expression Pattern	up-regulated
Function Description	LINC01133 was significantly increased in HCC cells including HepG2, Hep3B, MHCC 97L, SK Hep 1, and MHCC 97H cells compared with the normal human liver cell line HL 7702. In addition, PI3K/AKT signaling was highly activated in HCC cells. Knockdown of LINC01133 was able to inhibit HCC cell proliferation, cell colony formation, cell apoptosis, and blocked cell cycle arrest in the G1 phase. For another, downregulation of LINC01133 repressed HCC cell migration and invasion. Subsequently, the PI3K/AKT signaling pathway was strongly suppressed by silence of LINC01133 in Hep3B and HepG2 cells. Then, in vivo tumor xenografts models were established using Hep3B cells to explore the function of LINC01133 in HCC progression. Consistently, our study indicated that knockdown of LINC01133 dramatically repressed HCC tumor progression through targeting the PI3K/AKT pathway in vivo. Taken these together, we revealed that LINC01133 contributed to HCC progression by activating the PI3K/AKT pathway
Pubmed ID	30548306
Year	2018
Title	LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway

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