Basic Information
| LncRNA/CircRNA Name | LINC01133 |
| Synonyms | NA |
| Region | GRCh38_1:159961218-159984750 |
| Ensemble | ENSG00000224259 |
| Refseq | NR_038849 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | Human pancreatic cancer cell lines SW1990, Capan1, AsPc1, PANC-1, BxPC-3, and normal human pancreatic ductal cell line HPDE |
| Expression Pattern | up-regulated |
| Function Description | GSE32676 and GSE16515 revealed that LINC01133 was upregulated in pancreatic cancer, which was also associated with increased DKK1 methylation and higher expression of genes related to the Wnt signaling pathway, although the expression of DKK1 decreased in pancreatic cancer. In addition, LINC01133 bound to the promoter region of DKK1, resulting in the trimethylation of H3K27 and decreased DKK1 expression, while the expression of Wnt-5a, MMP-7, and ?-catenin increased upon LINC01133 binding. Finally, over-expressed LINC01133 enhanced the growth, proliferation, migration, metastasis, and invasion of pancreatic cancer cells. The present study clarified the distinct effect of LINC01133 on pancreatic cancer. |
| Pubmed ID | 30580676 |
| Year | 2019 |
| Title | Long non-coding RNA LINC01133 silencing exerts antioncogenic effect in pancreatic cancer through the methylation of DKK1 promoter and the activation of Wnt signaling pathway |
External Links
| Links for LINC01133 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |