Basic Information
| LncRNA/CircRNA Name | LINC01133 |
| Synonyms | NA |
| Region | GRCh38_1:159961218-159984750 |
| Ensemble | ENSG00000224259 |
| Refseq | NR_038849 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, other |
| Sample | OSCC tissues and cell lines (CAL27, HN4, and 293FT) |
| Expression Pattern | down-regulated |
| Function Description | Higher expression of LINC01133 in OSCCs was correlated with less metastasis and better prognosis. LINC01133 inhibited OSCC cell migration and invasion. RNA-seq data showed that LINC01133 inhibited GDF15, and GDF15 could rescue inhibition of OSCC cell migration and invasion caused by LINC01133. Interestingly, GDF15 also inhibited LINC01133. Furthermore, a significant negative correlation between expression of LINC01133 and GDF15 was validated in the clinical study. |
| Pubmed ID | 30332510 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC01133 Inhibits Oral Squamous Cell Carcinoma Metastasis Through a Feedback Regulation Loop With GDF15 |
External Links
| Links for LINC01133 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |