Basic Information
| LncRNA/CircRNA Name | LINC01133 |
| Synonyms | NA |
| Region | GRCh38_1:159961218-159984750 |
| Ensemble | ENSG00000224259 |
| Refseq | NR_038849 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR , Western blot , RIP , RNAi , in vitro knockdown etc. |
| Sample | human immortalized nasopharyngeal epithelial cell line (NP69) , human NPC cell lines (CNE-1, CNE-2, 5-8F, 6-10B,and SUNE-1) |
| Expression Pattern | down-regulated |
| Function Description | LINC01133 was significantly downregulated in NPC tissues and cell lines.LINC01133 inhibited NPC cell proliferation, invasion and migration both in vitro and in vivo. LINC01133 was observed mainly distributed in the nucleus.LINC01133 directly combined with YBX1, and YBX1 can partly reverse the repression of NPC cell proliferation, migration, and invasion caused by LINC01133. |
| Pubmed ID | 31106003 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC01133 Mediates Nasopharyngeal Carcinoma Tumorigenesis by Binding to YBX1 |
External Links
| Links for LINC01133 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |