Basic Information
| LncRNA/CircRNA Name | LINC01118 |
| Synonyms | NA |
| Region | GRCh38_2:46816668-46822657 |
| Ensemble | ENSG00000222005 |
| Refseq | NR_034099 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Paclitaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | serous cystadenoma tissues, borderline cystadenoma tissues, and serous cystadenocarcinoma tissues, SKOV3-TR30 cells,Human EOC cell lines SKOV3, A2780, and COC1,Paclitaxel-resistant cell lines SKOV3-TR30 and A2780,Platinum-resistant cell lines SKOV3-DDP and COC1/DDP,293T cells |
| Expression Pattern | up-regulated |
| Function Description | LINC01118 was highly expressed in EOC tissues and chemoresistant cells. Biological function experiments showed LINC01118 could facilitate paclitaxel resistance and promote migration and invasion while inhibiting apoptosis of EOC cells. Moreover, LINC01118 targets miR-134 and then affects ABCC1 expression. |
| Pubmed ID | 30521855 |
| Year | 2018 |
| Title | LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1 |
External Links
| Links for LINC01118 | GenBank HGNC NONCODE |
| Links for Epithelial ovarian cancer | OMIM COSMIC |