Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | LINC01116, TALNEC2 |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR, RNAi etc. |
| Sample | cell lines (PRECs, LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of LINC01116 with siRNA decreased proliferation of prostate cancer cells and significantly up-regulated several genes including GAPDH (regulates glycolysis), MAP1LC3B2 (autophagy) and H2AFY (chromatin structure). A four-fold decrease in the ability of the cancer cells to form colonies was found when the LINC01116 gene was disrupted through a CRISPR/CAS9 method, further supporting an oncogenic function for LINC01116 in PC-3 cells. |
| Pubmed ID | 28131897 |
| Year | 2017 |
| Title | Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |