Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | NA |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Human oral mucosal epithelial cells (OMECs) (SciL-0682, ATCC, Manassas, VA, USA), OSCC cell line (Tca83, ATCC, Manassas, VA, USA), OSCC tissues and adjacent tissues) |
| Expression Pattern | up-regulated |
| Function Description | LINC01116 and FN1 were abundant in both OSCC tissues and cells, while miR136 was poorly expressed. LINC01116 could competitively bind to miR-136, which targets and negatively regulates FN1. Moreover, in response to LINC01116 silencing or miR-136 over-expression, OSCC cells exhibited diminished EMT process and inhibited cell viability, invasion, and migration in vitro, coupling with impaired tumorigenicity and LNM in vivo. |
| Pubmed ID | 31308744 |
| Year | 2019 |
| Title | Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1 |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |