Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | TALNEC2 |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot, other |
| Sample | OSCC tissues and cell line (Cal-27) |
| Expression Pattern | up-regulated |
| Function Description | LINC01116 was also overexpressed in oral squamous cell carcinoma and nasopharyngeal carcinoma tissues, and LINC01116 silencing significantly inhibited the migration and invasion capacities of both cell lines by blocking the epithelial-mesenchymal transition process. In addition, 125 coexpressing genes were identified by circlncRNAnet, and were mainly located on human autosomes and enriched in transforming growth factor-? signaling pathway. These findings indicate that LINC01116 might be a potential therapeutic target for HNSCC. |
| Pubmed ID | 31452270 |
| Year | 2020 |
| Title | Knockdown of LINC01116 Inhibits Cell Migration and Invasion in Head and Neck Squamous Cell Carcinoma Through Epithelial-Mesenchymal Transition Pathway |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |