Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | NA |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, in vitro knockdown, Western blot analysis, Microarray analysis, Northern blotting, RNA-FISH analysis etc. |
| Sample | human glioma cell lines(U251, A172, U87MG, U118MG), human umbilical vein endothelia cells (HUVEC) and human embryonic kidney 293T (HEK293T) cell line ,glioma tissues , normal brain tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC01116 was significantly upregulated in glioma tissues and played an important role in cell proliferation, cycle, migration, invasion and angiogenesis. In addition, vascular endothelial growth factor (VEGFA) may be the major target genes in the downstream of lncRNA-LINC01116.LINC01116 and VEGFA both contained a miR-31-5p binding site, and LINC01116 could regulate the expression of VEGFA through competitive absorption of miR-31-5p.LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, There was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p. |
| Pubmed ID | 31144303 |
| Year | 2019 |
| Title | A Novel lncRNA-LINC01116 Regulates Tumorigenesis of Glioma by Targeting VEGFA |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |