Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | NA |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot |
| Sample | glioma tissues |
| Expression Pattern | up-regulated |
| Function Description | Linc01116 is highly expressed in glioma tissue and cells, along with low expression of miR-31, and there was a negative correlation between the expression of linc01116 and miR-31 in glioma tissue. In addition, the expression of linc01116 in glioma patients with metastasis was significantly higher than that in patients without metastasis, while miR-31 was significantly lower. In vitro and in vivo studies shown that linc01116 promoted invasion and migration of glioma cells. |
| Pubmed ID | 31933922 |
| Year | 2019 |
| Title | LncRNA linc01116 Prometes Glioma Cell Migration and Invasion by Modulation of Radixin Targeted by miR-31 |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |