Basic Information
| LncRNA/CircRNA Name | LINC01094 |
| Synonyms | NA |
| Region | GRCh38_4:78645903-78682699 |
| Ensemble | ENSG00000251442 |
| Refseq | NR_038303 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | cell lines (ACHN, 786-O, Caki-1 and 769-P) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of LINC01094 was also confirmed in ccRCC cell lines, and functional experiments delineated that LINC01094 knockdown led to inhibition on ccRCC cell growth and metastasis. Moreover, LINC01094 was activated by FOXM1 at the transcriptional level. Further assay demonstrated that LINC01094 worked as a sponge of microRNA 224-5p (miR-224-5p) and CHSY1 was a miR-224-5p-targeted mRNA. Further, we verified that LINC01094 acted as a competing endogenous RNA in ccRCC to regulate CHSY1 expression via competitively bind to miR-224-5p. |
| Pubmed ID | 31767633 |
| Year | 2019 |
| Title | FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1 |
External Links
| Links for LINC01094 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |