Basic Information
| LncRNA/CircRNA Name | LINC01089 |
| Synonyms | LINC01089, LIMT |
| Region | GRCh38_12:121795267-121803906 |
| Ensemble | ENSG00000212694 |
| Refseq | NR_002809 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Cell migration and invasion assay etc. |
| Sample | cell lines (MCF10A, MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | Functional analyses of this group uncovered LINC01089 (here renamed LncRNA Inhibiting Metastasis; LIMT), a highly conserved lncRNA, which is depleted in basal-like and in HER2-positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. We also find that LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo. |
| Pubmed ID | 27485121 |
| Year | 2016 |
| Title | LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. |
External Links
| Links for LINC01089 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |