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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth	2	Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	breast cancer
ICD-0-3	C50
Methods	qPCR, Western blot, other
Sample	BC tissues and cell lines (MDA-MB-231, BT549, SUM-159, MDA-MB-468, SK-BR-3, MCF-7, YCCB1, T47D)
Expression Pattern	down-regulated
Function Description	Low LINC01089 expression was significantly correlated with age (P=0.026), lymph node metastasis (P=0.003), and poor prognosis of patients with BC. According to the multivariate Cox regression analysis results, LINC01089 was an independent prognostic indicator of overall survival (P=0.032) and recurrence-free survival (P=0.014). Functional studies revealed significant decreases in the proliferation, migration, and invasion of tumor cells overexpressing LINC01089, and EGF could reverse above effects of LINC01089 on BC cells. Additionally, increased LINC01089 expression promoted apoptosis and cell cycle arrest at G0/G1 phase, accompanied by decreased expression of the key cell cycle regulators CDK4 and CDK6. Loss-of-function assays confirmed partial results. Mechanistically, LINC01089 blocked the Wnt/?-catenin pathway and the expression of downstream target genes by inhibiting ?-catenin expression at the transcriptional level.
Pubmed ID	31417284
Year	2019
Title	Long Noncoding RNA LINC01089 Predicts Clinical Prognosis and Inhibits Cell Proliferation and Invasion Through the Wnt/?-catenin Signaling Pathway in Breast Cancer

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