Basic Information
| LncRNA/CircRNA Name | LINC01088 |
| Synonyms | NA |
| Region | GRCh38_4:78971748-79308798 |
| Ensemble | ENSG00000249307 |
| Refseq | NR_038342 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | Microarray, RT-qPCR, Western blot, Luciferase reporter assay |
| Sample | malignant epithelial ovarian tumor tissue, human ovarian cancer cell line A2780 |
| Expression Pattern | down-regulated |
| Function Description | the expression of long intergenic non-coding RNA 1088 (LINC01088) was clearly reduced in benign epithelial ovarian tumor tissues compared to matched normal ovarian tissues. This was shown by global cDNA gene chip scanning and real-time qPCR, and validated in 42 clinical specimens.Furthermore, we found that LINC01088 inhibited the growth of ovarian cancer xenografts in nude mice.Correlation analysis between LINC01088 and mircoRNAs (miRNAs) conducted using primary clinical samples and RNA co-precipitation experiments revealed that miR-24-1-5p was one of the targets of LINC01088. Overexpression of miR-24-1-5p facilitated cell proliferation both in vitro and in vivo, however, LINC01088 could partially reverse the cell proliferation induced by miR-24-1-5p. |
| Pubmed ID | 29440672 |
| Year | 2018 |
| Title | LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p. |
External Links
| Links for LINC01088 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |