Basic Information
| LncRNA/CircRNA Name | LINC01060 |
| Synonyms | NA |
| Region | GRCh38_4:188400736-188681051 |
| Ensemble | ENSG00000249378 |
| Refseq | NR_033869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Microarray, RIP, etc. |
| Sample | pancreatic cancer tissues, cell lines (PANC-1, MIA-PaCa-2, ASPC-1, SW1990, BXPC-3, CFPAC-1, Panc 03.27, HPDE) |
| Expression Pattern | down-regulated |
| Function Description | Lower Linc01060 expression in pancreatic cancer tissues was significantly associated with a poor prognosis. Linc01060 inhibited pancreatic cancer proliferation and invasion in vitro and in vivo. These data demonstrate that Linc01060 plays a key role in suppressing pancreatic cancer progression by regulating vinculin expression. |
| Pubmed ID | 29913236 |
| Year | 2018 |
| Title | Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover. |
External Links
| Links for LINC01060 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |