Basic Information
| LncRNA/CircRNA Name | LINC01060 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | pancreatic cancer tissues, cell lines (PANC-1, MIA-PaCa-2, ASPC-1, SW1990,BXPC-3, CFPAC-1, Panc 03.27) |
| Expression Pattern | down-regulated |
| Function Description | Linc01060 showed the lowest expression in pancreatic cancer tissues compared with normal pancreatic tissues. Lower Linc01060 expression in pancreatic cancer tissues was significantly associated with a poor prognosis. Linc01060 inhibited pancreatic cancer proliferation and invasion in vitro and in vivo. Vinculin knockdown also accelerated pancreatic cancer cell proliferation by upregulating ERK activity. Linc01060 overexpression suppressed PC cell invasion and metastasisby inhibiting vinculin and upregulating FAK Y-397 and paxillin Y-118,thereby promoting focal adhesion turnover and enhancing cell motility. |
| Pubmed ID | 29913236 |
| Year | 2018 |
| Title | Loss of Linc01060 Induces Pancreatic Cancer Progression Through Vinculin-Mediated Focal Adhesion Turnover |
External Links
| Links for LINC01060 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |