Basic Information
| LncRNA/CircRNA Name | LINC01018 |
| Synonyms | NA |
| Region | GRCh38_5:6582136-6588499 |
| Ensemble | ENSG00000250056 |
| Refseq | NR_024423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP etc. |
| Sample | HCC tissues and adjacent normal tissues , Human HCC cells (HepG2, Hep3B, and Huh7) and human normal liver cells L-02 |
| Expression Pattern | down-regulated |
| Function Description | LINC01018 and FOXO1 were poorly expressed but miR-182-5p was highly expressed in HCC tissues and cells.The upregulation of LINC01018 was shown to decrease proliferation while promoting apoptosis of HCC cells.LINC01018 acted as a sponge of miR-182-5p, which targeted FOXO1.Last, mice injected with Hep3B overexpressing FOXO1 displayed suppressed xenograft tumor formation. |
| Pubmed ID | 31021172 |
| Year | 2019 |
| Title | LINC01018 Confers a Novel Tumor Suppressor Role in Hepatocellular Carcinoma Through Sponging microRNA-182-5p |
External Links
| Links for LINC01018 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |