Basic Information
| LncRNA/CircRNA Name | LINC01006 |
| Synonyms | NA |
| Region | GRCh38_7:156472196-156640654 |
| Ensemble | ENSG00000182648 |
| Refseq | NR_026865 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Microarray, RT-qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | PC and adjacent non-tumor tissue samples,PC cell lines including PANC-1, AsPC-1, SW1990, BxPC-3, the pancreatic duct epithelial cell line HPDE6-C7 and human renal epithelial cell line 293T |
| Expression Pattern | up-regulated |
| Function Description | The expression of LINC01006 was markedly upregulated in PC tissues and cells. Furthermore, LINC01006 knockdown inhibited PC cell proliferation, invasion and migration, and upregulation of LINC01006 led to the opposite results.In addition, the transcription factor HOXB8 could activate LINC01006 transcription in PC. |
| Pubmed ID | 31827394 |
| Year | 2019 |
| Title | LINC01006 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer via miR-2682-5p/HOXB8 Axis |
External Links
| Links for LINC01006 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |