Basic Information
| LncRNA/CircRNA Name | LINC00982 |
| Synonyms | NA |
| Region | GRCh38_1:3059615-3068437 |
| Ensemble | ENSG00000177133 |
| Refseq | NR_015440 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | PTC cell lines BHT101 and B-CPAP, PTC tissues and corresponding pericarcinomatous tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00982 was decreased in human PTC tissues. Patients with decreased LINC00982 expression levels had a reduced overall survival (p = 0.0019) compared with those with high LINC00982 expression levels. Overexpression of LINC00982 suppressed the proliferation and migration of BHT101 and B-CPAP cells and promoted cell apoptosis. Knockdown of LINC00982 promoted the proliferation and migration of BHT101 and B-CPAP cells and induced cell apoptosis. Moreover, in vivo assay showed that overexpression of LINC00982 could suppress the growth of PTC. Finally, LINC00982 could regulate the activity of PI3K/AKT signaling pathway in vitro and in vivo. |
| Pubmed ID | 31262968 |
| Year | 2019 |
| Title | Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway |
External Links
| Links for LINC00982 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |