Basic Information
| LncRNA/CircRNA Name | LINC00978 |
| Synonyms | AGD2, LINC00978, MIR4435-1HG, MORRBID, lncRNA-AWPPH,MIR4435-2HG |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Luciferase reporter assay, RIP, qPCR, Western blot, other |
| Sample | GC tissues and cell lines( BGC-823, AGS, SGC-7901, MGC-803) |
| Expression Pattern | up-regulated |
| Function Description | Up-regulation of LINC00978 was positively correlated with low survival rate. LINC00978 silence inhibited proliferation, metastasis, and promoted apoptosis in BGC-823 cells. Additionally, LINC00978 functioned as competing endogenous RNA to inhibit miR-497 expression. Further, NTRK3 was confirmed as a target gene of miR-497. Up-regulation of NTRK3 was found in GC tissues, and the positive correlation was presented between LINC00978 and NTRK3. Further, LINC00978 promoted cell proliferation and tumor weight by regulation of NTRK3. |
| Pubmed ID | 30452981 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC00978 Promotes Cell Proliferation and Tumorigenesis via Regulating microRNA-497/NTRK3 Axis in Gastric Cancer |
External Links
| Links for LINC00978 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |