Basic Information
| LncRNA/CircRNA Name | LINC00963 |
| Synonyms | NA |
| Region | GRCh38_9:129483451-129513686 |
| Ensemble | ENSG00000204054 |
| Refseq | NR_038955 |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | ABCG2, ABCB5 | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | head and neck cancer |
| ICD-0-3 | C76.0 |
| Methods | qPCR, in vitro knockdown |
| Sample | OSCC and normal paired noncancerous tissues, OSCC cell lines (SAS, GNM) |
| Expression Pattern | up-regulated |
| Function Description | Our results showed that the expression of the lncRNA LINC00963 was up-regulated in oral cancer tissues and CSCs. We found that the downregulation of LINC00963 inhibited CSC hallmarks, such as migration, invasion and colony formation capacity. |
| Pubmed ID | 32357409 |
| Year | 2020 |
| Title | LINC00963 Promotes Cancer Stemness, Metastasis, and Drug Resistance in Head and Neck Carcinomas via ABCB5 Regulation. |
External Links
| Links for LINC00963 | GenBank HGNC Noncode |
| Links for head and neck cancer | Omim Cosmic |