Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qRT-PCR , Western blot , RIP , in vitro knockdown etc.
Sample	preoperative blood samples of hepatocellular carcinoma patients, benign liver disease patients and healthy controls ,tumor and paired non-tumor tissues ,human hepatocellular carcinoma cell lines(7721,7402, HepG2, and LM3) ,human normal liver epithelial cell line 7702
Expression Pattern	up-regulated
Function Description	LINC00978 expression was upregulated in tumor tissues and serum of HCC patients. Higher serum levels of LINC00978 could distinguish HCC patients from hepatitis and liver cirrhosis patients and healthy controls. LINC00978 knockdown inhibited HCC cell proliferation, migration and invasion while promoted cell cycle arrest and apoptosis.LINC00978 knockdown also inhibited HCC growth and metastasis in mouse tumor models.LINC00978 bound to EZH2 and mediated its accumulation at the promoter region of p21 and E-cadherin genes, leading to the trimethylation of H27K3 and the inhibition of p21 and E-cadherin expression. Moreover, the simultaneous depletion of p21 and E-cadherin expression reversed the inhibitory effects of LINC00978 knockdown on HCC cell proliferation, migration, and invasion.
Pubmed ID	31582742
Year	2019
Title	LINC00978 Promotes the Progression of Hepatocellular Carcinoma by Regulating EZH2-mediated Silencing of p21 and E-cadherin Expression

External Links