Basic Information
| LncRNA/CircRNA Name | LINC00974 |
| Synonyms | NA |
| Region | GRCh38_17:41549606-41554495 |
| Ensemble | ENSG00000226629 |
| Refseq | NR_038442 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot |
| Sample | OSCC tissues,cell line |
| Expression Pattern | up-regulated |
| Function Description | In invasion and migration assay, miR-122 overexpression resulted in reduced, whereas LINC00974 and RhoA overexpression resulted in increased rate of cancer cell migration and invasion. In addition, miR-122 overexpression reduced the effects of LINC00974 overexpression. |
| Pubmed ID | 31702382 |
| Year | 2019 |
| Title | LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral Squamous Cell Carcinoma |
External Links
| Links for LINC00974 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |