Basic Information
| LncRNA/CircRNA Name | LINC00968 |
| Synonyms | NA |
| Region | GRCh38_8:56496246-56559823 |
| Ensemble | ENSG00000246430 |
| Refseq | NR_038236 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | cell lines (U2OS, MG63, Saos-2, SW1353, 143-B, hFOB) |
| Expression Pattern | up-regulated |
| Function Description | overexpression of LINC00968 promoted osteosarcoma cell survival and cell colony formation ability in Saos-2 and 143-B cells. In addition, LINC00968 was able to induce osteosarcoma cell migration and invasion through up-regulating MMP-2 and MMP-9 protein levels. Knockdown of LINC00968 inactivated PI3K/AKT/mTOR signaling pathway in vitro. |
| Pubmed ID | 29904919 |
| Year | 2018 |
| Title | LINC00968 functions as an oncogene in osteosarcoma by activating the PI3K/AKT/mTOR signaling. |
External Links
| Links for LINC00968 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |